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Prof.Guosong Chen
Room B4080, Chemistry/Macromolecular Building, Department of Macromolecular Science, Jiangwan Campus of Fudan University, Shanghai 200438, CHINA
Phone/Fax: 86-21-31244275
Email: guosong@fudan.edu.cn
Homepage: http://www.polymer.fudan.edu.cn/polymer/research/CGSJM/EN/Default.aspx

Education and Working Experience


Ph. D. candidate (with Prof. Yu. Liu), Department of Chemistry, Nankai University


Postdoctoral Research Associate (with Prof. Nicola L. Pohl), Iowa State University,

Ames, IA, United States Glycochemistry: solution-phase automated synthesis of antigen

oligosaccharides and their microarray diagnosis of infected serum


Lecturer, Department of Macromolecular Sciences, Fudan University


Associate Professor, Department of Macromolecular Sciences, Fudan University

Macromolecular self-assembly and artificial glycocalyx systems


Professor, Department of Macromolecular Sciences, Fudan University

Research Interests

  • Protein assemblies driven by carbohydrate-protein interactions
  • Glyco-assemblies and their immunological properties
  • Carbohydrate chemistry as a new driving force of self-assembly
  • Macromolecular self-assembly inspired by supramolecular chemistry

Representative Publications

  1. Gao CD, Chen GS*. Exploring and Controlling the Polymorphism in Supramolecular Assemblies of Carbohydrates and Proteins, Acc. Chem. Res. 2020, 53: 740-751.
  2. Li Z, Chen SY, Gao CD, Yang ZW, Shih KC, Kochovski Z, Yang G, Gou L, Nieh MP, Jiang M, Zhang L*, Chen GS*. Chemically Controlled Helical Polymorphism in Protein Tubes by Selective Modulation of Supramolecular Interactions, J. Am. Chem. Soc. 2019, 141: 19448-19457.
  3. Yang G, Zheng W, Tao GQ, Wu LB, Zhou QF, Kochovski Z, Ji T, Chen HJ, Li XP, Lu Y, Ding HM*, Yang HB*, Chen GS*, Jiang M. Diversiform and Transformable Glyco-Nanostructures Constructed from Amphiphilic Supramolecular Metallocarbohydrates through Hierarchical Self-Assembly: The Balance between Metallacycles and Saccharides, ACS Nano 2019, 13: 13474-13485.
  4. Zheng W, Wang W, Jiang ST, Yang G, Li Z, Wang XQ, Yin GQ, Zhang Y, Tan HW, Li XP, Ding HM*, Chen GS*, Yang HB*. Supramolecular Transformation of Metallacycle-Linked Star Polymers Driven by Simple Phosphine Ligand-Exchange Reaction, J. Am. Chem. Soc. 2019, 141: 583-591. 
  5. Qi WJ, Zhang YF, Wang J, Tao GQ, Wu LB, Kochovski Z, Gao HJ, Chen GS*, Jiang M. Deprotection-induced morphology transition and immuno-activation of glyco-vesicles: a strategy of smart delivery polymersomes, J. Am. Chem. Soc., 2018, 140: 8851-8857.
  6. Zhang YF, Wu LB, Li Z, Zhang WY, Luo FF, Chu YW, Chen GS*. Glycocalyx-Mimicking Nanoparticles Improve Anti-PD-L1 Cancer Immunotherapy through Reversion of Tumor-Associated Macrophages, Biomacromolecules 2018, 19: 2098-2108. 
  7. Wu LB, Zhang YF, Li Z, Yang G, Kochovski Z, Chen GS*, Jiang M. "Sweet" Architecture-Dependent Uptake of Glycocalyx-Mimicking Nanoparticles Based on Biodegradable Aliphatic Polyesters by Macrophages, J. Am. Chem. Soc. 2017, 139: 14684-14692.
  8. Yang G, Ding HM, Kochovski Z, Hu RT, Lu Y, Ma YQ*, Chen GS*, Jiang M. Highly ordered self-assembly of native proteins into 1D, 2D and 3D structures modulated by a tether length of inducing ligands, Angew. Chem. Int. Ed. 2017, 56: 10691-10695.
  9. Lin MC, Chen GS*. An Efficient Protein Modification Method Based on Dynamic Covalent Bonding between Sugar and Phenylboronic Acid, Acta Polymerica Sinica 2017, 7: 1113-1120.
  10. Liu YJ, Zhang YF, Wang ZY, Wang J, Wei KC, Chen GS*, Jiang M. Building Nanowires from Micelles: Hierarchical Self-assembly of Alternating Amphiphilic Glycopolypeptide Brushes with Pendants of High-Mannose Glycodendron and Oligophenylalanine, J. Am Chem. Soc. 2016, 138: 12387-12394.

Honors and Awards

  • Fellow of Royal Society of Chemistry (FRSC)
  • 2018 ACS PMSE Young Investigator Award
  • 2018 Nano Research Young Innovator Awards (NR45) 

Academic Service

  • Associate Editor ACS Macro Letters 
  • Editorial Advisory Board Polymer Chemistry, Bioconjugate Chemistry, Polymer International, J. Macro. Sci. Part A.

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