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Prof.Guosong Chen
Room B4080, Chemistry/Macromolecular Building, Department of Macromolecular Science, Jiangwan Campus of Fudan University, Shanghai 200438, CHINA
Phone/Fax: 86-21-31244275
Email: guosong@fudan.edu.cn
Homepage: http://www.polymer.fudan.edu.cn/polymer/research/CGSJM/EN/Default.aspx


Education and Working Experience

09/2001-06/2006

Ph. D. candidate (with Prof. Yu. Liu), Department of Chemistry, Nankai University

08/2006-12/2008

Postdoctoral Research Associate (with Prof. Nicola L. Pohl), Iowa State University,

Ames, IA, United States Glycochemistry: solution-phase automated synthesis of antigen

oligosaccharides and their microarray diagnosis of infected serum

12/2008-10/2011

Lecturer, Department of Macromolecular Sciences, Fudan University

10/2011-10/2014

Associate Professor, Department of Macromolecular Sciences, Fudan University

Macromolecular self-assembly and artificial glycocalyx systems

10/2014-now

Professor, Department of Macromolecular Sciences, Fudan University

Research Interests

  • Protein assemblies driven by carbohydrate-protein interactions

  • Glyco-assemblies and their immunological properties

  • Carbohydrate chemistry as a new driving force of self-assembly

  • Macromolecular self-assembly inspired by supramolecular chemistry

Representative Publications

1.  Ye LF, Dong XD, Wang C, Lin Y, Lee M, Li L*, Chen GS*. Helical protein nanotubules assembled from sacrificial supramolecular polymers. Nature Synthesis, 2025, doi:10.1038/s44160-024-00726-y.

2.   Yang MS, Rao GB, Li L, Qi LL, Ma C, Zhang H, Gong J, Wei B, Zhang XE, Chen GS*, Cao S*, and Li F*.Transformation of a Viral Capsid from Nanocages to Nanotubes and Then to Hydrogels: Redirected Self-Assembly and Effects on Immunogenicity. ACS Nano 2024, 18, 21: 13755-13767.

3. Liu RY, Zhang R, Dong XD, Chen SY, Zhang L, Shi TF, Yuan JY, Hedin N, and Chen GS*.Chirality Transfer of Glycopeptide across Scales Defined by the Continuity of Hydrogen Bonds. ACS Nano 2024, 18, 22: 14367-14376.

4.   Li L, Ye LF, Shi YW, Yin L, Chen GS*. Liquid Phase Exfoliation of Protein Parent Crystals into Nanosheets and Fibrils Based on Orthogonal Supramolecular Interactions. J. Am. Chem. Soc. 2024, 146: 31992−32002.

5.   Liu RY, Li L, Chen SY, Yang ZW, Kochovski Z, Mei SL, Lu Y, Zhang L*, and Chen GS*. Evolution of Protein Assemblies Driven by the Switching of Interplay Mode. ACS Nano 2023, 17, 3: 2245-2256.

6.   Li L, Li Z, Wang ZY, Chen SY, Liu RY, Xu XY, Zhang Z, Ye LF, Ding Y, Luo Q, Cao S, Zhang L, Imberty A, and Chen GS*. Spatiotemporal Landscape for the Sophisticated Transformation of Protein Assemblies Defined by Multiple Supramolecular Interactions. ACS Nano 2023, 17: 15001-15011.

7.   Li L, and Chen GS*. Precise Assembly of Proteins and Carbohydrates for Next-Generation Biomaterials. J. Am. Chem. Soc. 2022, 144, 36: 16232-16251.

8.   Wu LB, Cheng L, Yang J, Yan YF, Zhang ES, Kochovski Z, Li L, Wang Z, Deng LF, Lu Y, Besenius P, Cui W *, and Chen GS*. Construction of Active Protein Materials: Manipulation on Morphology of Salmon Calcitonin Assemblies with Enhanced Bone Regeneration Effect. Advanced Materials 2022, 34, 2207526.

9.   Liu RY, Zhang R, Li L, Kochovski Z, Yao LT, Nieh MP, Lu Y, Shi TF, and Chen GS*. A Comprehensive Landscape for Fibril Association Behaviors Encoded Synergistically by Saccharides and Peptides. J. Am. Chem. Soc. 2021, 143, 17: 6622-6633.

10. Su L, Feng YL, Wei KC, Xu XY, Liu RY, and Chen GS*. Carbohydrate-Based Macromolecular Biomaterials. Chem. Rev. 2021, 121, 18: 10950-11029.

Honors and Awards

  • Hui Yongzheng Sugar Science Award for Young Innovation (2022)

  • National Natural Science Foundation of China Outstanding Youth Fund (2021)

  • Innovation Paper Award of the Chinese Chemical Society in Polymer Science (2019)

  • Young Innovation Academic Lecture Award of the Chinese Chemical Society in Supramolecular Chemistry (2019)

  • Outstanding Young Award of the Biomedical Polymer Materials Branch of the Chinese Society for Biomaterials (2019)

  • ACS PMSE Young Investigator Award (2018)

  • Nano Research Young Innovator Awards (NR45) in Nanobiotech (2018)

  • Outstanding Young Talent of the Organization Department of the CPC Central Committee (2014)

  • National Natural Science Foundation of China's Excellent Young Scientists Fund (2013)

  • Shanghai Municipal Education Commission's Dawn Program (2013)

  • Shanghai Science and Technology Commission's Young Science and Technology Rising Star Program (Class A) (2013)

  • Feng Xinde Polymer Award (2012, shared with Professor Jiang Ming)

  • Selected for the 18th Nobel Laureate Meeting (2006)

Academic Service

  • Member of the Scientific Advisory Board of the Max Planck Institute for Polymer Research, Germany (since 2025)

  • Associate Editor of ACS Macro Letters, American Chemical Society (since 2018)

  • Fellow of the Royal Society of Chemistry (FRSC) (since 2017)

  • Vice Chairperson of the Applied Chemistry Division, Chinese Chemical Society (since 2022)

  • Vice Chairperson of the Supramolecular Chemistry Division, Chinese Chemical Society (since 2022)

  • Member of the Polymer Division, Chinese Chemical Society (since 2018)

  • Member of the Young Chemists Committee, Chinese Chemical Society (since 2015)

  • Member of the Carbohydrate Chemistry Division, Chinese Chemical Society (since 2022)

  • Member of the Biomedical Polymer Materials Branch, Chinese Society for Biomaterials (since 2019)

  • Member of the Molecular Characterization Division of the Polymer Division, Chinese Chemical Society (since 2022)

  • Served as an international advisory board member for Biomacromolecules, Carbohydrate Research, Polymer Chemistry (2018 - 2019), Bioconjugate Chemistry, Polymer International and Journal of Macromolecular Science, Part A.

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