+565 975 658
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Monday - Friday, 8.00 - 20.00
Prof.Guosong Chen
Room B4080, Chemistry/Macromolecular Building, Department of Macromolecular Science, Jiangwan Campus of Fudan University, Shanghai 200438, CHINA
Phone/Fax: 86-21-31244275
Email: guosong@fudan.edu.cn
Homepage: http://www.polymer.fudan.edu.cn/polymer/research/CGSJM/EN/Default.aspx
Education and Working Experience
| 09/2001-06/2006 | Ph. D. candidate (with Prof. Yu. Liu), Department of Chemistry, Nankai University |
| 08/2006-12/2008 | Postdoctoral Research Associate (with Prof. Nicola L. Pohl), Iowa State University, Ames, IA, United States Glycochemistry: solution-phase automated synthesis of antigen oligosaccharides and their microarray diagnosis of infected serum |
| 12/2008-10/2011 | Lecturer, Department of Macromolecular Sciences, Fudan University |
| 10/2011-10/2014 | Associate Professor, Department of Macromolecular Sciences, Fudan University Macromolecular self-assembly and artificial glycocalyx systems |
| 10/2014-now | Professor, Department of Macromolecular Sciences, Fudan University |
Research Interests
- Protein assemblies driven by carbohydrate-protein interactions
- Glyco-assemblies and their immunological properties
- Carbohydrate chemistry as a new driving force of self-assembly
- Macromolecular self-assembly inspired by supramolecular chemistry
Representative Publications
- Gao CD, Chen GS*. Exploring and Controlling the Polymorphism in Supramolecular Assemblies of Carbohydrates and Proteins, Acc. Chem. Res. 2020, 53: 740-751.
- Li Z, Chen SY, Gao CD, Yang ZW, Shih KC, Kochovski Z, Yang G, Gou L, Nieh MP, Jiang M, Zhang L*, Chen GS*. Chemically Controlled Helical Polymorphism in Protein Tubes by Selective Modulation of Supramolecular Interactions, J. Am. Chem. Soc. 2019, 141: 19448-19457.
- Yang G, Zheng W, Tao GQ, Wu LB, Zhou QF, Kochovski Z, Ji T, Chen HJ, Li XP, Lu Y, Ding HM*, Yang HB*, Chen GS*, Jiang M. Diversiform and Transformable Glyco-Nanostructures Constructed from Amphiphilic Supramolecular Metallocarbohydrates through Hierarchical Self-Assembly: The Balance between Metallacycles and Saccharides, ACS Nano 2019, 13: 13474-13485.
- Zheng W, Wang W, Jiang ST, Yang G, Li Z, Wang XQ, Yin GQ, Zhang Y, Tan HW, Li XP, Ding HM*, Chen GS*, Yang HB*. Supramolecular Transformation of Metallacycle-Linked Star Polymers Driven by Simple Phosphine Ligand-Exchange Reaction, J. Am. Chem. Soc. 2019, 141: 583-591.
- Qi WJ, Zhang YF, Wang J, Tao GQ, Wu LB, Kochovski Z, Gao HJ, Chen GS*, Jiang M. Deprotection-induced morphology transition and immuno-activation of glyco-vesicles: a strategy of smart delivery polymersomes, J. Am. Chem. Soc., 2018, 140: 8851-8857.
- Zhang YF, Wu LB, Li Z, Zhang WY, Luo FF, Chu YW, Chen GS*. Glycocalyx-Mimicking Nanoparticles Improve Anti-PD-L1 Cancer Immunotherapy through Reversion of Tumor-Associated Macrophages, Biomacromolecules 2018, 19: 2098-2108.
- Wu LB, Zhang YF, Li Z, Yang G, Kochovski Z, Chen GS*, Jiang M. "Sweet" Architecture-Dependent Uptake of Glycocalyx-Mimicking Nanoparticles Based on Biodegradable Aliphatic Polyesters by Macrophages, J. Am. Chem. Soc. 2017, 139: 14684-14692.
- Yang G, Ding HM, Kochovski Z, Hu RT, Lu Y, Ma YQ*, Chen GS*, Jiang M. Highly ordered self-assembly of native proteins into 1D, 2D and 3D structures modulated by a tether length of inducing ligands, Angew. Chem. Int. Ed. 2017, 56: 10691-10695.
- Lin MC, Chen GS*. An Efficient Protein Modification Method Based on Dynamic Covalent Bonding between Sugar and Phenylboronic Acid, Acta Polymerica Sinica 2017, 7: 1113-1120.
- Liu YJ, Zhang YF, Wang ZY, Wang J, Wei KC, Chen GS*, Jiang M. Building Nanowires from Micelles: Hierarchical Self-assembly of Alternating Amphiphilic Glycopolypeptide Brushes with Pendants of High-Mannose Glycodendron and Oligophenylalanine, J. Am Chem. Soc. 2016, 138: 12387-12394.
Honors and Awards
- Fellow of Royal Society of Chemistry (FRSC)
- 2018 ACS PMSE Young Investigator Award
- 2018 Nano Research Young Innovator Awards (NR45)
Academic Service
- Associate Editor ACS Macro Letters
- Editorial Advisory Board Polymer Chemistry, Bioconjugate Chemistry, Polymer International, J. Macro. Sci. Part A.
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