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Prof.Guosong Chen
Room B4080, Chemistry/Macromolecular Building, Department of Macromolecular Science, Jiangwan Campus of Fudan University, Shanghai 200438, CHINA
Phone/Fax: 86-21-31244275
Email: guosong@fudan.edu.cn
Homepage: http://www.polymer.fudan.edu.cn/polymer/research/CGSJM/EN/Default.aspx

Education and Working Experience


Ph. D. candidate (with Prof. Yu. Liu), Department of Chemistry, Nankai University


Postdoctoral Research Associate (with Prof. Nicola L. Pohl), Iowa State University,

Ames, IA, United States Glycochemistry: solution-phase automated synthesis of antigen

oligosaccharides and their microarray diagnosis of infected serum


Lecturer, Department of Macromolecular Sciences, Fudan University


Associate Professor, Department of Macromolecular Sciences, Fudan University

Macromolecular self-assembly and artificial glycocalyx systems


Professor, Department of Macromolecular Sciences, Fudan University

Research Interests

  • Protein assemblies driven by carbohydrate-protein interactions
  • Glyco-assemblies and their immunological properties
  • Carbohydrate chemistry as a new driving force of self-assembly
  • Macromolecular self-assembly inspired by supramolecular chemistry

Representative Publications

1.Wenjing Qi, Yufei Zhang, Jue Wang, Guoqing Tao, Libin Wu, Zdravko Kochovski, Hongjian Gao, Guosong Chen*, Ming Jiang, “Deprotection-induced morphology transition and immuno-activation of glyco-vesicles: a strategy of smart delivery polymersomes” J. Am. Chem. Soc., 2018, 140, 8851-8857.

2.Yufei Zhang, Libin Wu, Zhen Li, Weiyi Zhang, Feifei Luo, Yiwei Chu, Guosong Chen*, “Glycocalyx-Mimicking Nanoparticles Improve Anti-PD-L1 Cancer Immunotherapy through Reversion of Tumor-Associated Macrophages” Biomacromolecules 2018, 19, 2098-2108. (Invited in Biomacromolecules Asian Special Issue)

3.Libin Wu, Yufei Zhang, Zhen Li, Guang Yang, Zdravko Kochovski, Guosong Chen*, Ming Jiang, “"Sweet" Architecture-Dependent Uptake of Glycocalyx-Mimicking Nanoparticles Based on Biodegradable Aliphatic Polyesters by Macrophages” J. Am. Chem. Soc.2017, 139, 14684-14692.

4.Wei Zheng, Guang Yang, Nannan Shao, Li-Jun Chen, Bo Ou, Shu-Ting Jiang, Guosong Chen*, Haibo Yang*, “CO2 Stimuli-Responsive, Injectable Block Copolymer Hydrogels Cross-linked by Discrete Organoplatinum(II) Metallacycles via Stepwise Post-Assembly Polymerization”, J. Am. Chem. Soc., 2017, 139, 13811-13820.

5.Guang Yang, Hong-ming Ding, Zdravko Kochovski, Rongting Hu, Yan Lu, Yu-qiang Ma*, Guosong Chen*, Ming Jiang “Highly ordered self-assembly of native proteins into 1D, 2D and 3D structures modulated by a tether length of inducing ligands”, Angew. Chem. Int. Ed2017, 56, 10691-10695.

6.Yu Zhao, Yufei Zhang, Changchun Wang, Guosong Chen*, Ming Jiang, “Role of Protecting Groups in Synthesis and Self-Assembly of Glycopolymers”, Biomacromolecules 2017, 18, 568-575.

7.Zhen Li, Liang Sun, Yufei Zhang, Andrew P Dove, Rachel K. O'Reilly*, Guosong Chen*, “Shape Effect of Glyco-Nanoparticles on Macrophage Uptake and Immune Response”, ACS Macro Lett.2016, 5, 1059-0164.

8.Yijiang Liu, Yufei Zhang, Zheyu Wang, Jue Wang, Kongchang Wei, Guosong Chen*, Ming Jiang, “Building Nanowires from Micelles: Hierarchical Self-assembly of Alternating Amphiphilic Glycopolypeptide Brushes with Pendants of High-Mannose Glycodendron and Oligophenylalanine”, J. Am Chem. Soc. 2016, 138, 12387-12394. 

9.Guang Yang, Libin Wu, Guosong Chen*, Ming Jiang, “Precise Protein Assembly to Array Structures”, Chem. Commun.2016, 52, 10595-10605.

10.Zhongwei Ji, Junfang Li, Guosong Chen*, Ming Jiang, “Fate of Host-Stabilized Charge Transfer Complexation Based on Cucurbit[8]uril: Inducing Cyclization of PNIPAM and Dissociation in Self-Assembly of the Cyclic Polymer”, ACS Macro Lett2016, 5, 588-592.

11.Wei Zheng, Li-Jun Chen, Guang Yang, Bin Sun, Xu Wang, Bo Jiang, Guang-Qiang Yin, Li Zhang, Xiaopeng Li, Minghua Liu, Guosong Chen*, Haibo Yang*, “Construction of Smart Supramolecular Polymeric Hydrogels Cross-linked by Discrete Organoplatinum(II) Metallacycles via Post-Assembly Polymerization”, J. Am. Chem. Soc., 2016, 138, 4927-4937.

12.Guang Yang, Xiang Zhang, Zdravko Kochovski, Yufei Zhang, Bin Dai, Fuji Sakai, Lin Jiang, Yan Lu, Matthias Ballauff, Xueming Li, Cong Liu*, Guosong Chen*, Ming Jiang, “Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions”, J. Am. Chem. Soc., 2016, 138, 1932-1937.

Honors and Awards

  • Fellow of Royal Society of Chemistry (FRSC)
  • 2018 ACS PMSE Young Investigator Award
  • 2018 Nano Research Young Innovator Awards (NR45) 

Academic Service

  • Associate Editor ACS Macro Letters 
  • Editorial Advisory Board Polymer Chemistry, Bioconjugate Chemistry, Polymer International, J. Macro. Sci. Part A.

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