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Prof.Guosong Chen
Room B4080, Chemistry/Macromolecular Building, Department of Macromolecular Science, Jiangwan Campus of Fudan University, Shanghai 200438, CHINA
Phone/Fax: 86-21-31244275
Email: guosong@fudan.edu.cn
Homepage: http://www.polymer.fudan.edu.cn/polymer/research/CGSJM/EN/Default.aspx

Education and Working Experience

09/2001-06/2006

Ph. D. candidate (with Prof. Yu. Liu), Department of Chemistry, Nankai University

08/2006-12/2008

Postdoctoral Research Associate (with Prof. Nicola L. Pohl), Iowa State University,

Ames, IA, United States Glycochemistry: solution-phase automated synthesis of antigen

oligosaccharides and their microarray diagnosis of infected serum

12/2008-10/2011

Lecturer, Department of Macromolecular Sciences, Fudan University

10/2011-10/2014

Associate Professor, Department of Macromolecular Sciences, Fudan University

Macromolecular self-assembly and artificial glycocalyx systems

10/2014-now

Professor, Department of Macromolecular Sciences, Fudan University

Research Interests

  • Protein assemblies driven by carbohydrate-protein interactions
  • Glyco-assemblies and their immunological properties
  • Carbohydrate chemistry as a new driving force of self-assembly
  • Macromolecular self-assembly inspired by supramolecular chemistry

Representative Publications

1.Wenjing Qi, Yufei Zhang, Jue Wang, Guoqing Tao, Libin Wu, Zdravko Kochovski, Hongjian Gao, Guosong Chen*, Ming Jiang, “Deprotection-induced morphology transition and immuno-activation of glyco-vesicles: a strategy of smart delivery polymersomes” J. Am. Chem. Soc., 2018, 140, 8851-8857.

2.Yufei Zhang, Libin Wu, Zhen Li, Weiyi Zhang, Feifei Luo, Yiwei Chu, Guosong Chen*, “Glycocalyx-Mimicking Nanoparticles Improve Anti-PD-L1 Cancer Immunotherapy through Reversion of Tumor-Associated Macrophages” Biomacromolecules 2018, 19, 2098-2108. (Invited in Biomacromolecules Asian Special Issue)

3.Libin Wu, Yufei Zhang, Zhen Li, Guang Yang, Zdravko Kochovski, Guosong Chen*, Ming Jiang, “"Sweet" Architecture-Dependent Uptake of Glycocalyx-Mimicking Nanoparticles Based on Biodegradable Aliphatic Polyesters by Macrophages” J. Am. Chem. Soc.2017, 139, 14684-14692.

4.Wei Zheng, Guang Yang, Nannan Shao, Li-Jun Chen, Bo Ou, Shu-Ting Jiang, Guosong Chen*, Haibo Yang*, “CO2 Stimuli-Responsive, Injectable Block Copolymer Hydrogels Cross-linked by Discrete Organoplatinum(II) Metallacycles via Stepwise Post-Assembly Polymerization”, J. Am. Chem. Soc., 2017, 139, 13811-13820.

5.Guang Yang, Hong-ming Ding, Zdravko Kochovski, Rongting Hu, Yan Lu, Yu-qiang Ma*, Guosong Chen*, Ming Jiang “Highly ordered self-assembly of native proteins into 1D, 2D and 3D structures modulated by a tether length of inducing ligands”, Angew. Chem. Int. Ed2017, 56, 10691-10695.

6.Yu Zhao, Yufei Zhang, Changchun Wang, Guosong Chen*, Ming Jiang, “Role of Protecting Groups in Synthesis and Self-Assembly of Glycopolymers”, Biomacromolecules 2017, 18, 568-575.

7.Zhen Li, Liang Sun, Yufei Zhang, Andrew P Dove, Rachel K. O'Reilly*, Guosong Chen*, “Shape Effect of Glyco-Nanoparticles on Macrophage Uptake and Immune Response”, ACS Macro Lett.2016, 5, 1059-0164.

8.Yijiang Liu, Yufei Zhang, Zheyu Wang, Jue Wang, Kongchang Wei, Guosong Chen*, Ming Jiang, “Building Nanowires from Micelles: Hierarchical Self-assembly of Alternating Amphiphilic Glycopolypeptide Brushes with Pendants of High-Mannose Glycodendron and Oligophenylalanine”, J. Am Chem. Soc. 2016, 138, 12387-12394. 

9.Guang Yang, Libin Wu, Guosong Chen*, Ming Jiang, “Precise Protein Assembly to Array Structures”, Chem. Commun.2016, 52, 10595-10605.

10.Zhongwei Ji, Junfang Li, Guosong Chen*, Ming Jiang, “Fate of Host-Stabilized Charge Transfer Complexation Based on Cucurbit[8]uril: Inducing Cyclization of PNIPAM and Dissociation in Self-Assembly of the Cyclic Polymer”, ACS Macro Lett2016, 5, 588-592.

11.Wei Zheng, Li-Jun Chen, Guang Yang, Bin Sun, Xu Wang, Bo Jiang, Guang-Qiang Yin, Li Zhang, Xiaopeng Li, Minghua Liu, Guosong Chen*, Haibo Yang*, “Construction of Smart Supramolecular Polymeric Hydrogels Cross-linked by Discrete Organoplatinum(II) Metallacycles via Post-Assembly Polymerization”, J. Am. Chem. Soc., 2016, 138, 4927-4937.

12.Guang Yang, Xiang Zhang, Zdravko Kochovski, Yufei Zhang, Bin Dai, Fuji Sakai, Lin Jiang, Yan Lu, Matthias Ballauff, Xueming Li, Cong Liu*, Guosong Chen*, Ming Jiang, “Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions”, J. Am. Chem. Soc., 2016, 138, 1932-1937.

Honors and Awards

  • Fellow of Royal Society of Chemistry (FRSC)
  • 2018 ACS PMSE Young Investigator Award
  • 2018 Nano Research Young Innovator Awards (NR45) 

Academic Service

  • Associate Editor ACS Macro Letters 
  • Editorial Advisory Board Polymer Chemistry, Bioconjugate Chemistry, Polymer International, J. Macro. Sci. Part A.

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